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6 edition of The kinetochore found in the catalog.

The kinetochore

The kinetochore

from molecular discoveries to cancer therapy

by

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Published by Springer in New York, London .
Written in English

    Subjects:
  • Chromosomes,
  • Cell organelles

  • Edition Notes

    Includes bibliographical references and index.

    StatementPeter De Wulf, William C. Earnshaw, editors.
    ContributionsDe Wulf, Peter., Earnshaw, William C.
    Classifications
    LC ClassificationsQH600 .K56 2009
    The Physical Object
    Paginationxiii, 509 p. :
    Number of Pages509
    ID Numbers
    Open LibraryOL23391735M
    ISBN 100387690735
    ISBN 109780387690735
    LC Control Number2008935380


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The kinetochore Download PDF EPUB FB2

“The Kinetochore: from Molecular Discoveries to Cancer Therapy” presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and “model” eukaryotic species, and at natural and mutant neocentromeres.

Recently initiated translational research on kinetochores is also discussed as kinetochores are Author: Peter De Wulf. " The Kinetochore: from Molecular Discoveries to Cancer Therapy " edited by Peter De Wulf and William C.

Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and The kinetochore book eukaryotic species, and at natural and mutant cturer: Springer. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C.

Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres.

Recently initiated translational research on kinetochores is also discussed as kinetochores. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and 'model' eukaryotic species, and at natural and mutant neocentromeres.

average of and papers cite the kinetochore and centromere, respectively (Pubmed). This research avalanche has resulted in an almost unmanageable amount of data. Unfortunately, since the publication of his outstanding book by Andy Choo over a decade ago (K.

Choo, The Centromere, Oxford University Press, New York, ), so much has been. The kinetochore. Cheeseman IM(1). Author information: (1)Whitehead Institute and Department of Biology, MIT Nine Cambridge Center, Cambridge, Massachusetts A critical requirement for mitosis is the distribution of genetic material to the two daughter cells.

The kinetochore is a fascinating molecular machine that plays a central role in the fundamental processes that are required for the recognition, connections, and force generation that underlie mitosis.

The kinetochore (which consists of CEN DNA and associated proteins) is a macromolecular complex that is critical to the process of chromosome segregation. The kinetochore is responsible for mediating attachment of sister chromatids to the spindle microtubules (MTs) and for directing chromosome movement during mitosis and meiosis [17, 18].Cited by:   The kinetochore is an assembly of more than 50 different proteins (Hauk S, Watanabe Y Cell ).

A synthetic lethal and synthetic dosage lethal screen in yeast identified genes controlling kinetochore function (Measday V et al Proc Natl Acad Sci USA ).

"The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition, formation, regulation, and activity, both in mitosis and meiosis, in humans and "model" eukaryotic species, and at natural and mutant neocentromeres.

The Kinetochore: From Molecular Discoveries to Cancer Therapy by Peter De Wulf, William Earnshaw Published by Springer. Measuring inter-kinetochore distances is a useful assay to gauge inter-kinetochore tension generation (Waters et al., ) and thus the presence of stable kinetochore–MT attachments.

View chapter Purchase book. The Kinetochore Iain M. Cheeseman Whitehead Institute and Department of Biology, MIT Nine Cambridge Center, Cambridge, Massachusetts Correspondence: [email protected] A critical requirement for mitosis is the distribution of genetic material to the two daughter cells.

The central player in this process is the macromolecular kinetochore. "The Kinetochore: from Molecular Discoveries to Cancer Therapy" edited by Peter De Wulf and William C. Earnshaw presents a thorough up-to-date analysis of kinetochore and centromere composition.

been made in studying the yeast kinetochore. This chapter will examine, and compare where possible, the various kinds of. interactions that occur between kinetochores and microtubules at different. Book: Concepts in Biology (OpenStax) 6: Reproduction at the Cellular Level Expand/collapse global location The kinetochore breaks down and the sister chromatids separate.

The nucleus re-forms and the cell divides. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. The Kinetochore and Mitosis: Focus on the Regulation and Correction Mechanisms of Chromosome-to-Microtubule Attachments.

By Rita M. Reis and Hassan Bousbaa. Submitted: April 18th Reviewed: January 19th Published: April 25th DOI: /Author: Rita M.

Reis, Hassan Bousbaa. The ultrastructure of the vertebrate kinetochore is described based on early electron microscopy (EM) studies employing glutaraldehyde fixation that identified kinetochores as trilaminar structures, approximately nm wide and 80 nm deep, with an electron-opaque inner plate juxtaposed to the centromeric chromatin, a translucent gap layer, and an electron-opaque, chromatin-distal outer plate Cited by: Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters.

Kinetochores also control feedback mechanisms responsible for the correction of incorrect microtubule attachments, and for the coordination of chromosome attachment with cell cycle by: Centromeres and the kinetochore proteins that bind them are required for chromosome segregation during eukaryotic cell division.

Despite this conserved function, both centromeric DNA and kinetochore proteins evolve rapidly. This chapter hypothesizes that this paradox can be explained by an on-going conflict between selfish centromeric DNA elements and the DNA binding proteins of the kinetochore.

3) The kinetochore becomes attached to the cohesin proteins. Sister chromatids line up at the metaphase plate. The kinetochore breaks down and the sister chromatids separate. The nucleus reforms and the cell divides. 4) The kinetochore becomes attached to the mitotic spindle.

Sister chromatids line up at the metaphase plate. The Ndc80 complex is a key component of kinetochore that mediates direct interaction with spindle microtubules.

These authors present a cryo-electron microscopy reconstruction of. Define kinetochore. kinetochore synonyms, kinetochore pronunciation, kinetochore translation, English dictionary definition of kinetochore.

Either of two submicroscopic attachment points for chromosomal microtubules, present on each centromere during the process of cell division. The Kinetochore or Spindle Fibre Locus in Amphiuma Tridactylum.

Item Information. Condition: Very Good. Price: US $ The Kinetochore or Spindle Fibre Locus in Amphiuma Tridactylum. Sign in to check out Check out as guest. Book must be returned in the same condition as sent. All autographs are guaranteed authentic, and if found Seller Rating: % positive.

Posts about Kinetochore written by Midnight Knitter. Today is World Scleroderma t the Niagara Falls will be illuminated blue and white in recognition of the day. All this month (June) there have been walks and outreach to raise awareness of this disease and to raise money for scleroderma research, and scleroderma patients all over the world have been urged to post pictures of their.

Bill Brinkley had first described the kinetochore in the s. He saw, by electron microscopy, a trilaminar, proteinaceous disc structure that flanked the centromere (Brinkley and Stubblefield, ).But further details were obscure for another 20 : Kendall Powell.

Start studying Chapter 12 Book Questions. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. Create. Log in Daughter chromosomes were observed to move toward the poles faster than the marked regions of fluorescently labeled kinetochore microtubules.

Evaluate each of the following defects, which could. The kinetochore becomes attached to the mitotic spindle. Sister chromatids line up at the metaphase plate. The kinetochore breaks apart and the sister chromatids separate. The nucleus re-forms and the cell divides. Citation/Attribution.

Want to cite, share, or modify this book. This book is Creative Commons Attribution License and you must. The cell cycle is an ordered series of events involving cell growth and cell division that produces two new daughter cells. Cells on the path to cell division proceed through a series of precisely timed and carefully regulated stages of growth, DNA replication, and division that produce two genetically identical cells.

Cryo-electron microscopy structures of the Saccharomyces cerevisiae inner kinetochore complex provide insights into the interdependencies of constituent subcomplexes and the mechanism of Cited by: 5.

Kinetochore also known as centromere is present in each. chromosome. During metaphase, spindle fibers get attached to the. kinetochore and during anaphase, the chromosomes are pulled apart.

Spindle and kinetochore-associated protein 2 is a protein that in humans is encoded by the SKA2 gene found in chromosome SKA2 is a part of a spindle and kinetochore associated complex also including SKA1 and SKA3 which is responsible for onset of the anaphase in mitosis by regulating chromosomal segregation.

SKA2 may function as a prognostic gene marker for identifying lung cancer as well HGNC: The mitosis is the process of the cell division, which occurs in all the somatic cells present in the body of the multicellular organism.

The mitosis is divided into four phases, prophase, metaphase, anaphase and telophase. Option (b): centrosome. The centrosome is a structure present in the poles. Kinetochores are huge. The simplest ones contain more than proteins. This makes sense, considering the kinetochore’s hefty responsibility—connecting chromosomes to the long, thin microtubules that tug them to one end of a dividing cell.

Its work is essential to ensuring new cells receive the appropriate allotment of chromosomes. Janelia Farm Research Campus group leader. BUB1 and BUBR1 consist of three main regions. One of these regions is the C-terminus. This region is a catalytic serine/threonine protein domain. The other region is the N-terminal region which is conserved in BUBR1 and BUB1, as well as their homologs.

The N-terminal region contains the kinetochore localization domain. We showed previously that dam interacts genetically with the kinetochore components ctf19Δ, bir1Δ, ipl, and sli but not with mutants in the CBF3 complex or mif (Cheeseman et al., ; Kang et al., ).

To extend this genetic analysis, we crossed dam to a wide range of mutants that affect kinetochore by: pole attach to the kinetochore on the other sister chromatid. The microtubules that are attached to the kinetochores are called kinetochore microtubules. Equal and opposite force is applied from each end of the spindle.

Each side tries to pull the chromosomes toward its own spindle pole. At metaphase, because the forces in opposite directions are equal, there is no movement in either direction. METAPHASE: Kinetochore microtubules connect to the centromere.

ANAPHASE: Kinetochore microtubules pull the chromatids apart into individual chromosomes and pull them towards the centrosomes at the periphery.

All of this allows the cell to divide properly with each daughter cell containing full complements of chromosomes. Genes for three maize homologs (CenpcA, CenpcB, and CenpcC) of the conserved kinetochore assembly protein known as centromere protein C (CENPC) have been identified.

The C-terminal portion of maize CENPC shares similarity with mammalian CENPC and its yeast homolog Mif2p over a 23–amino acid region known as region I.

Immunolocalization experiments combined with three Cited by: If the microtubule-kinetochore connection is severed at metaphase, the cell will be prevented from progressing (Nicklas, R.B., et al, J. Cell Biol. ). However, if an equivalent tension is applied by tugging on the chromosome with a glass microneedle, progression of mitosis is restored!.

Metaphase starts with alignment of sister chromatids on the metaphase the alignment is done, the spindle fibers will come and attach to the kinetochore of the chromatids. The cohesion protein helps in the tight binding of the kinetochore and spindle the attachment is done, the sister chromatids are pulled apart towards the pole.The mitosis is the process of the cell division, which takes place in all the somatic cells present in the body of a multicellular organism.

The mitosis is divided into four phases, i.e., prophase, metaphase, anaphase and telophase. In the prophase stage, the genetic material condenses to form the.Figure Which of the following is the correct order of events in mitosis? a. Sister chromatids line up at the metaphase plate. The kinetochore becomes attached to the mitotic spindle.

The nucleus re-forms and the cell divides. The sister chromatids separate. b. The kinetochore becomes attached to the mitotic spindle.

The sister chromatids.